AKT inhibitor VIII ( AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730 )

Catalog No. M15308 CAS No. 612847-09-3

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Product Name

AKT inhibitor VIII
Note

Research use only, not for human use.
Brief Description

A selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively.
Description

A selective, allosteric Akt inhibitor with IC50 of 58/210 for Akt1/2 respectively; shows weak activity for Akt3 (IC50=2.12 uM); inhibits basal and IGF stimulated Akt1 and Akt2 phosphorylation in mouse lung, with no effect on Akt3 phosphorylation.
Synonyms

AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt1;Akt2;Akt3
Research Area

Cancer
Indication

——

CAS Number

612847-09-3
Formula Weight

551.64
Molecular Formula

C34H29N7O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1N(C2CCN(CC3=CC=C(C4=NC5=CC6=C(N=CN6)C=C5N=C4C7=CC=CC=C7)C=C3)CC2)C8=CC=CC=C8N1
Chemical Name

2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-

1. Lindsley, et al. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.
2. Romorini L, et al. Sci Rep. 2016 Oct 20;6:35660.

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